プレイオトロフィン結合性および非結合性のコンドロイチン硫酸/デルマタン硫酸オリゴ糖
- 专利权人:
- 独立行政法人科学技術振興機構
- 发明人:
- 菅原 一幸,バオ シンフォン
- 申请号：
- JP2005197587
- 公开号：
- JP5344785B2
- 申请日:
- 2005.07.06
- 申请国别(地区):
- JP
- 年份:
- 2013
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a new sulfated oligosaccharide useful as a reagent for study for elucidating the structure and function of chondroitin sulfate and dermatan sulfate having various kinds of bioactivities.
SOLUTION: The pleiotrophin (PTN)-binding or nonbinding sulfated oligosaccharide is isolated and purified by fragmenting chondroitin sulfate/dermatan sulfate hybrid chain (E-CS/DS) derived from embryonic pig brain, and subjecting the resultant fragments to an affinity chromatography or the like using a column for immobilizing the PTN which mediates neurite extension-promoting activities. Structures of many kinds of new sulfated oligosaccharides are determined by subjecting the resultant oligosaccharides to structural analysis. The PTN-binding sulfated oligosaccharide in them can be utilized as a PTN function regulator for binding with the PTN and regulating the function.
COPYRIGHT: (C)2007,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
