NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA
发明人:
KISHI, HIROYUKI,MURAGUCHI, ATSUSHI,HAMANA, HIROSHI,KOBAYASHI, EIJI,OZAWA, TATSUHIKO
申请号：
EP13758671
公开号：
EP2824182A4
申请日:
2013.03.06
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
An object of the present invention is to stimulate a T cell without using a peptide/MHC tetramer. In the present invention, the step of supplying an antigen peptide to a T cell having a T cell receptor (TCR) that can recognize the antigen peptide on cell surface to form a complex of a major histocompatibility complex (MHC) molecule on the cell surface of the T cell and the antigen peptide is used, and the T cell is stimulated through recognition by TCR of the antigen peptide as the MHC molecule-antigen peptide complex on the cell surface of the same T cell. Such a stimulating and activating method would be applicable to not only T cells, but also various cells. According to the present invention, an antigen-specific T cell can be identified without establishing any antigen-specific T cell strain, and without using such a reagent as MHC/peptide tetramer. That is, a cancer-specific T cell can be efficiently and conveniently identified.
