LUO, SULAN,ZHANGSUN, DONGTING,WU, YONG,ZHU, XIAOPENG,HU, YUANYAN,BING, HUI,MCINTOSH, J., MICHAEL
申请号：
EP13828357
公开号：
EP2889307A4
申请日:
2013.06.18
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides a novel ±-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The ±-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as ±3²2 nAChRs, ±6/±3²2²3 nAChR or ±3²4 nAChR or ±6/±3²4 nAChR), has activity for treatment of neuralgia, addiction, Parkinsons disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.
