A composition for use in treating hair loss in a subject, wherein the composition comprises an agent that stimulates one or more members of the SHH signaling pathway, and a non-therapeutic method for treating hair loss in a subject, the method comprising administering a composition comprising an agent that stimulates one or more members of the SHH signaling pathway to the subject. The agent may be a glioma-associated oncogene homolog 1 (GLI1) polypeptide, a glioma-associated oncogene homolog 2 (GLI2) polypeptide, a biologically active fragment thereof, or a homolog thereof.
