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T-cell expansion method and uses
专利权人:
TCER AB
发明人:
Grönlund, Hans
申请号:
AU2018287169
公开号:
AU2018287169A1
申请日:
2018.06.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The invention provides a method for the expansion of anti-tumor T-cells, comprising the steps of: a) providing a phagocytosable particle, having one or more tumor neoantigenic constructs tightly associated thereto, wherein the tumor neoantigenic construct comprises an amino-acid sequence comprising at least one mutated amino acid known or suspected to be associated with a cancer in a subject, or a mutated or non-mutated amino-acid sequence known or suspected to be expressed in a cancer cell in the subject; b)providing a viable antigen-presenting cell; c)contacting the particle with the antigen-presenting cell in vitro under conditions allowing phagocytosis of the particle by the antigen-presenting cell; d)providing a T-cell sample comprising viable T-cells from the subject; e)contacting the T-cell sample with the antigen-presenting cell contacted with the particle in vitrounder conditions allowing specific activation of anti-tumor T-cells in response to antigen presented by the antigen-presenting cell. The invention also provides tumor neoantigenic constructs as defined in the specification.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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