NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF

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专利权人:

PROCELL THERAPEUTICS, INC.; INC.;주식회사 프로셀테라퓨틱스;PROCELL THERAPEUTICS

发明人:

LEE, BYUNG KYU,이병규,LIM, JUNG HEE,임정희,LEE, BYUNG KYUKR,LIM, JUNG HEEKR

申请号：

KR1020160039707

公开号：

KR1020160068704A

申请日:

2016.03.31

申请国别(地区):

KR

年份:

2016

代理人:

摘要：

The present invention relates to a novel macromolecule transduction domain (MTD) peptides which facilitate the transverse of biological active molecules crossing a cell membrane. Also, the present invention relates to a polynucleotide encoding the MTD peptides, a method of identifying the MTD peptides, a method of genetically engineering biologically active molecules to have cell permeability by using the MTD peptides, a method of importing biologically active molecules into a cell by using the MTD peptides, and uses thereof. The MTD peptides of the present invention have single hydrophobic region on N-terminals of the MTD peptides, and form a helix structure while exhibiting flexibility. The MTD peptides have amino acids having a relatively short length, and has an amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 193, analogue, derivative, amidated mutation, and conservative mutation thereof.본 발명은 세포막을 가로지로는 생물학적 활성 분자의 횡단을 용이하게 하는 신규한 거대분자 전달 도메인(MTD) 펩티드를 기술한다. 상기 MTD 펩티드를 인코딩(encoding)하는 폴리뉴클레오티드, 상기 MTD 펩티드를 동정하는 방법, 상기 MTD 펩티드를 이용하여 생물학적 활성 분자가 세포 투과성을 갖도록 유전적으로 조작하는 방법, 상기 MTD 펩티드를 이용하여 세포 내로 생물학적 활성 분자를 유입시키는 방법, 및 이의 용도가 또한 기술된다.

来源网站：

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