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Using the compositions and compounds for increasing the survival time of cancer patients
专利权人:
バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド
发明人:
ハウシェール,フレデリック,エイチ.,ハウシェール,フレデリック,エイチ.
申请号:
JP2010550651
公开号:
JP5667886B2
申请日:
2008.07.15
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in time of survival in cancer patients, wherein the cancer either: (i) overexpresses thioredoxin or glutaredoxin and/or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and/or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth 'aggressiveness' of the particular cancer and treatment responsiveness of the particular type of cancer. Further, the present invention discloses and claims novel pharmaceutical compositions, methods, and kits used for the treatment of patients with medical conditions and disease where there is the overexpression of thioredoxin and/or glutaredoxin, and wherein this overexpression is associated with deleterious physiological effects in the patients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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