Systems and methods for detecting dried test strips are provided, where a dried test strip may be one that has been re-inoculated with a biological sample after having already been previously inoculated with another sample at an earlier time (e.g., hours or days before). In various aspects, a biosensor such as an amperometric glucose biosensor ("meter") (200) may apply one or more input electrical signals to an inoculated test strip (100) having at least a pair of electrodes (102,104) in contact with the biological sample. The meter (200) may measure output current value (s) resulting in response to the input electrical signals applied to the test strip (100). The meter (200) may determine whether the test strip is a dried test strip by comparing a ratio of the measured output current value (s) with a boundary ratio value.