594923 Provided are processes for preparing (E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydro- pyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide) and salts thereof. The compound and its salts can act as antivirals that inhibit hepatitis C virus (HCV). Also provided are intermediates that can be used in the preparation of the compound and its salts, pharmaceutical compositions comprising them and methods of use of such compositions.