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Prolinamide-tetrazole derivatives as NK3 receptor antagonists
专利权人:
F. Hoffmann-La Roche AG
发明人:
Wu, Xihan,Nettekoven, Matthias,Han, Bo,Knust, Henner,Ratni, Hasane
申请号:
AU2008258664
公开号:
AU2008258664B2
申请日:
2008.05.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to a compound of formula (I) : wherein Ris cycloalkyl or is phenyl unsubstituted or substituted by one or two halogenatoms R is hydrogen or halogen R is hydrogen, CN, loweralkoxy, lower alkyl or halogen n is 0, 1 or 2 or to a pharmaceutically suitableacid addition salt thereof. It has been found that the present compounds are highpotential NK-3 receptor antagonists for the treatment of depression, pain,psychosis, Parkinsons disease, schizophrenia, anxiety and attentiondeficit hyperactivity disorder (ADHD).
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