Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA

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专利权人:

Edmond J. Lavoie

发明人:

Edmond J. Lavoie,Joseph E. Rice,Leroy F. Liu

申请号：

US12258208

公开号：

US08093235B2

申请日:

2008.10.24

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention provides compounds of formula I:wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.

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