A pharmaceutical composition for the treatment of metabolic diseases comprising the fermentative products of Kalopanax septemlobus as an active ingredient
김진만,김성필,박선주,이화영,인수아,장원희,성은영,이명선,남석현,이상종,KIM JEAN MAN,KIM SUNG PHIL,PARK SEON JU,LEE WHA YOUNG,IN SUA,JANG WON HUI,SEONG EUN YOUNG,LEE MYOUNG SUN,NAM SEOK HYUN,LEE SANG JONG
申请号：
KR1020190128294
公开号：
KR1020200043294A
申请日:
2019.10.16
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a food composition for the treatment of metabolic disease, which includes the Eum tree fermentation as an active ingredient. Some studies on anti-inflammatory effects, anti-diabetic, cholesterol-lowering and hyperlipidemia-inhibiting effects, and anti-rheumatic effects have been reported in relation to the pharmacological effects of Eum trees. The application has not actually been made. In the field of oriental medicine, the antibacterial and anti-inflammatory effects of soum trees have been disclosed, and technologies for the treatment of tuberculosis or acne have been developed. -It has been reported that anti-diabetic and anti-obesity effects can be expected for extracts of Nemusun from promoting the secretion of GLP-1 from H716 cells, but it has not been demonstrated through animal experiments. However, this pharmacological effect of Eum tree is almost related to the anti-inflammatory effect by the inhibitory ability of NF-κB, so it was found that no more effect was given even if a large amount was additionally administered above a certain dose. Therefore, even if a large amount is consumed in relation to the metabolic disease, Eum tree shows only a limited effect. The Eum tree, or Eum tree fermentation product of the present invention has a remarkable relieving effect on various metabolic disease indicators in individuals with metabolic disease induced by high-fat diet. In particular, the fermented soybean fungus mycelia, or bioconverted fermented by additional enzymatic treatment, has a more remarkable effect on alleviating metabolic disease indicators than the unfermented soybean tree raw material, so it is greatly used in the treatment of complex metabolic diseases in medicine It is expected to be used.본 발명은 음나무발효물을 유효성분으로 포함하는 대사질환 치료용 약학조성물 및 식품조성물에 관한 것이다. 음나무의 약리작용과 관련하여 항염증 효과, 항당뇨 작용, 콜레스테롤 저하 및 고지혈증 억제 작용, 항류마티스 작용 등에 관한 연구가 일부 보고되었으나 실제 사람을 대상으로 대사질환과 관련하여 효과가 입증되거나, 처방 및 임상적용이 실제 이루어지
