The present invention relates to a monoclonal antibody that inhibits immunosuppressive functions of pathogens H. pylori, antigen-binding fragment thereof, and hybridomas producing such antibody. The monoclonal antibody or antigen-binding fragment thereof binds to a peptide consisting an amino acid sequence represented by MEKVGKDGVIVE (SEQ ID NO: 1), a fragment of HpHSP60. The present invention also discloses use of the invented monoclonal antibody or antigen-binding fragment thereof, as functional inhibitor against the immunosuppressive functions of H. pylori, and method of preparation for such hybridomas.
