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Immunoregulator compounds
专利权人:
Maurizio Fraziano
发明人:
Maurizio Fraziano,Sanjay Kumar Garg,Antonio Ciaramella,Giovanni Auricchio,Elisabetta Volpe,Angelo Martino,Patrizia Morena Baldihi,Paolo De Vito,Domenico Galati,Vittorio Colizzi
申请号:
US10496497
公开号:
US08377910B2
申请日:
2002.11.21
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically Mycobacterium tuberculosis. Such compounds are characterized in that they stimulate macrophagic Phospholipase D (PLD) (FIG. 1). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides.
来源网站:
中国工程科技知识中心
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