SALFELD JOCHEN G,ALLEN DEBORAH J,KAYMAKCALAN ZEHRA,LABKOVSKY BORIS,MANKOVICH JOHN A,MCGUINESS BRIAN T,ROBERTS ANDREW J,SAKORAFAS PAUL,HOOGENBOOM HENDRICUS R J M,SCHOENHAUT DAVID,VAUGHAN TRISTAN J,WHIT
申请号：
NZ61472797
公开号：
NZ614727A
申请日:
1997.02.10
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is an isolated human anti-human TNF-alpha antibody comprising: - a light chain variable region (LCVR) comprising a CDR3 domain comprising the amino acid sequence of SEQ ID NO: 3 (QRYNRAPYT/A), a CDR2 domain comprising the amino acid sequence of SEQ ID NO: 5 (AASTLQS), and a CDR1 domain comprising the amino acid sequence of SEQ ID NO: 7 (RASQGIRNYLA) and - a heavy chain variable region (HCVR) comprising a CDR3 domain comprising the amino acid sequence of SEQ ID NO: 4 (VSYLSTASSLDY/N), a CDR2 domain comprising the amino acid sequence of SEQ ID NO: 6 (AITWNSGHIDYADSVEG), and a CDR1 domain comprising the amino acid sequence of SEQ ID NO: 8 (DYAMH), wherein the antibody comprises an IgG1 heavy chain constant region and a kappa light chain constant region.
