HONG, Seok Hyun,LEE, Yoon-Jung,SAH, Hong Kee,LEE, Bong-Yong,UM, Key-An,OH, Joon-gyo,HWANG, Yong Youn,KIM, Hong-Kee,LEE, Kyu Ho
申请号：
KRKR2011/005347
公开号：
WO2012/011740A2
申请日:
2011.07.20
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a method for preparing microsphere1- and microspheres produced by thereby. More particularly, the present invention relates to a method for preparing a polymeric microsphere comprising the steps of: mixing a water-insoluble organic solvent with a dispersion solvent mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent so as to prepare an emulsion and adding a base or an acid to the prepared emulsion so as to remove the water-insoluble organic solvent from the emulsion and a polymeric microsphere thereby, and a composition for drug delivery comprising the microspheres. In the inventive preparation method, it is possible to conveniently prepare a drug-containing polymeric microsphere within a short time using a small amount of water, with the generation of a minimized amount of waste solution without a requirement of a conventional solvent-evaporation or solvent-extract ion process. Also, since a low concentration of remaining solvent within a prepared polymeric microsphere can be maintained, it is effective in preparation in sustained-release type medicines.Cette invention concerne un procédé de préparation de microsphères et les microsphères produites par ce procédé. Linvention concerne plus particulièrement un procédé de préparation dune microsphère polymère, ledit procédé consistant à : mélanger un solvant organique insoluble dans leau avec un solvant de dispersion mélanger un composé polymère, un médicament et un solvant organique insoluble dans leau de manière à obtenir une phase dispersée mélanger la phase dispersée avec le solvant de dispersion mélangé avec le solvant organique insoluble dans leau de manière à préparer une émulsion et ajouter une base ou un acide à lémulsion obtenue de manière à extraire de lémulsion le solvant organique insoluble dans leau et une microsph
