WAKO PURE CHEMICAL INDUSTRIES, LTD.;TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
申请号：
EP06007072.9
公开号：
EP1693054B1
申请日:
2001.08.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physlologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
