The present invention relates to a composition comprising at least one mimotope of an epitope of the amyloid-beta-peptide (Aβ) for use in preventing and/or treating synucleinopathies and/or ameliorating motor and/or cognitive symptoms of synucleopathies, wherein said at least one mimotope is coupled or fused to a pharmaceutically acceptable carrier protein selected from the group consisting of a non-toxic diphtheria toxin mutant, keyhole limpet hemocyanin (KLH), diphtheria toxin (DT), tetanus toxid (TT) and Haemophilus influenzae protein D (protein D).
