A method for assessing male reproductive health is disclosed. In some embodiments, the method comprises screening a sperm sample for sperm DNA accelerated decondensation (SDAD), for sperm DNA fragmentation index (DFI) and/or for delayed sperm DNA decondensation (SDD). The method is useful in the screening and clinical management of reproductively challenged human couples and for assessing reproductive health of potential sperm donors. A method is also provided for selecting an assisted reproductive technology (ART) best suited for a particular donor sperm sample. An automated method for assessing SDAD and SDD test scores is also disclosed, as well as an automated sperm processing protocol for preparing sperm for analysis of SDAD and SDD.
