Compounds of the following formula are provided for use with MEK:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.本發明提供用於MEK之下式之化合物:其中變數係如本文所定義。亦提供包含該等化合物之醫藥組合物,套組及製造物件;適於製造該等化合物之方法及中間物;及使用該等化合物之方法。