CYCLOHEXENE DERIVATIVE PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASE COMPRISING THE SAME AS ACTIVE INGREDIENT
LTD.;HYUNDAI PHARM CO., LTD.;HYUNDAI PHARM CO.;현대약품 주식회사
发明人:
YANG, JIN,양진,KIM, JIN WOONG,김진웅,LEE, HAN KYU,이한규,KIM, JAE HYUN,김재현,SON, CHANG MO,손창모,LEE, KYU HWAN,이규환,HWANG, JEONG UN,황정운,CHOI, HYUNG HO,최형호,KIM, DAE HOON,김대훈,RHEE, JAE KEOL,이재걸,YANG, JINKR,KIM, JIN WOONGKR,LEE, HAN KYUKR,KIM, JAE HYUNKR,SON, CHANG MOKR,LEE, KYU HWANKR,HWANG, JEONG UNKR,CHOI, HYUNG HOKR,KIM, DAE HOONKR,RHEE, JAE KEOLKR
申请号：
KR1020160142921
公开号：
KR1020170053118A
申请日:
2016.10.31
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a cyclohexene derivative, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating metabolic diseases. The cyclohexene derivative according to the present invention increases the activity of cAMP (cyclic adenosine monophosphate) in the cell by activating GPR-119 (G protein-coupled receptor 119), and has simultaneous effects of weight loss and blood sugar reduction by inducing the release of a neuroendocrine protein, GLP-1 (glucagon-like peptide-1) and thus may be beneficially used as a pharmaceutical composition for preventing or treating metabolic diseases including obesity, type I diabetes, type II diabetes, inappropriate insulin resistance, insulin resistance syndrome, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, X syndrome, and the like.본 발명은 싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 싸이클로 헥센 유도체는 GPR-119(G protein-coupled receptor 119)를 활성화시켜 cAMP(Cyclic adenosine monophosphate)의 세포 내 활성을 증가시키고, 신경 내분비 단백질인 GLP-1(Glucagon-like peptide-1) 방출을 유도하여 체중감소 및 혈당강하 효과가 동시에 나타나므로, 비만, I형 당뇨병, Ⅱ형 당뇨병, 부적합한 내당증, 인슐린 내성증, 고혈당증, 고지질혈증, 고중성지방혈증, 고콜레스테롤혈증, 이상지질혈증, X 증후군 등과 같은 대사성 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용할 수 있다.
