Compositions, methods of manufacture, methods of improving dietary health, kits, devices, and uses for plasma activated water are provided. Plasma activated water may be used for improving nitric oxide levels, improving health and/or reducing symptoms of cardiometabolic syndrome in a subject. Compositions and methods for improving nitric oxide levels in a subject disclosed herein comprise consumption of a composition comprising dietary nitrate contained in plasma activated water. The health benefits of consuming plasma activated water include lowering blood pressure, lowering intraocular pressure, decreasing LDL/TG levels, restoring nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation in nitric oxide deficient subjects. In addition, consumption of plasma activated water also improves oral health and reduces and/or prevents cancer burden. In an embodiment, plasma activated water may also benefit general health, as nitric oxide deficiencies correlate to numerous physiological aberrations, such as cancer.
