The invention relates to the preparation of composition including ACV,B1 B2, B6,B12,folic acid and niacin. There are different concentrations of ACV available, but most effective concentration for this purpose is 5% . when you add niacin 60mg vitamin Bl 4mg, B2 4mg, B6 2mg ,B12 4.0 meg, folic acid 6000mcg in 100ml of ACV. and mix well, keep it for one hour and then the solution is ready for use .We know that atherosclerotic CVD is leading cause of death in world wide .Its treatment, morbidity and mortality is one of the main financial burden for all countries. The new above mentioned ACV based composition for atherosclerotic CVD is very efficient and cost effective with minimal avoidable side effects . Even though ACV is used safely since antiquity as medicine for many years while adding above mentioned molecules active against atherogenesis .