COMPOUNDS

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专利权人:

ENTERPRISE THERAPEUTICS LIMITED

发明人:

COLLINGWOOD, Stephen,MCCARTHY, Clive,HARGRAVE, Jonathan,HAY, Duncan,SCHOFIELD, Thomas,ELLAM, Sarah,BUXTON, Craig,HABGOOD, Matthew,INGRAM, Peter,MA, Chun Yan,NAPIER, Spencer,SHAIKH, Abdul,SMITH, Matthe

申请号：

SG11202006067X

公开号：

SG11202006067XA

申请日:

2019.01.25

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

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