Disclosed is a method for topical protection against atmospheric pollutant molecules and ultraviolet (UV) radiation, comprising the steps of: a) producing a polymer matrix which is both repellent and anti-adhesive to atmospheric pollutant molecules, by means of a first biocompatible polymer (PB1); b) under the effect of the UV radiation, photocatalytically degrading the pollutant molecules having penetrated the polymer matrix by means of first semiconductor colloids (Col-1) onto which a second biocompatible polymer (PB2) has been grafted, which results in the formation of free radicals; c) neutralizing said free radicals by means of at least 2 antioxidants, which are: - a first antioxidant in the form of second semiconductor colloids (Col-2) onto which the first antioxidant (AntiOx-1) has been covalently grafted, said second grafted colloids (Col-2) auto-regenerating under the effect of the UV radiation, - and a second antioxidant agent (AntiOx-2) that is not present in the form of colloids grafted with an antioxidant; and d) stabilizing the polymer matrix by means of the second antioxidant agent (AntiOx-2).Procédé de protection topique, vis-à-vis des molécules polluantes atmosphériques et du rayonnement ultraviolet (UV), comprenant les étapes de : a) former une matrice polymérique répulsive et antiadhésive vis-à-vis des molécules polluantes atmosphériques, au moyen d'un premier polymère biocompatible (PB1); b) dégrader par photocatalyse sous l'effet du rayonnement UV les molécules polluantes ayant pénétré dans la matrice polymérique au moyen de premiers colloïdes semi- conducteurs greffés (Col-1) avec un second polymère biocompatible (PB2), entrainant de fait, la formation de radicaux libres; c) neutraliser lesdits radicaux libres au moyen d'au moins 2 antioxydants respectivement : - un premier antioxydant se présentant sous la forme de seconds colloïdes semi-conducteurs (Col-2) greffés de manière covalente avec ledit premier antioxydant (AntiOx-1); les seconds col