PROBLEM TO BE SOLVED: To provide orally disintegrating tablets which can reduce the odor and bitter taste derived from olmesartan medoxomil.SOLUTION: An orally disintegrating tablet containing a fine granule having a nuclear containing an active pharmaceutical ingredient containing olmesartan medoxomil in the center, as well as a barrier layer containing at least one kind selected from polyvinyl alcohol and vinyl alcohol copolymer and a water-insoluble polymer layer containing a water-insoluble polymer without an amino group in order from a side of the active pharmaceutical ingredient and an outer filler composition with respect to the fine granule.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】オルメサルタンメドキソミルに由来する臭い及び苦味を低減することが可能な口腔内崩壊錠の提供。【解決手段】オルメサルタンメドキソミルを含む原薬含有核を中心に有し、原薬含有核側から順に、ポリビニルアルコール及びビニルアルコール系共重合体から選択される少なくとも1種を含むバリア層、並びにアミノ基を有しない水不溶性のポリマーを含む水不溶性ポリマー層を有する細粒と、細粒に対して外側の賦形成分と、を含む口腔内崩壊錠。【選択図】なし
