These modular compounds selectively control and / or inhibit the transformation of signals through certain Native 500 enzyme proteins and / or mutations involved in various human or animal diseases, such as cell, metabolite, allergy and degenerative diffusion disorders. More specifically, these compounds have powerful and selective c-kit national and / or mutante.requiremene 1 inhibitors: a formula compound (1),Or a pharmaceutically acceptable salt, characterized by: A is a heterocycle of 5 or 6 members； R1 is hydrogen, halogen, C1-10 tar group, C1-10 tioalquilo group or C1-10 Alcoy group； R2 is halogen, arilo group, C1-10 halide group or C1-10 tar, which can be replaced by at least one alternative. The heteroatoms are selectively replaced by C1-10 halogenated tar or C1-10 tar which is selectively replaced by dissolving group； the Alcoy C1-10, tioalquilo C1-10 or C1-10 halogenated alcoxi group； and the coor, NRR and rsqoe groups；-NR-CO-R,-CONRR,-So2nrr rsqoe； o-nr-so2-r rsqoe； R and R rsqoe； respectively select an alternative group from the hydrogen group, arilo group, heteromorphic group and C1-10 tar group, which is replaced by at least one alternative heteroatom, one alternative C1-10 tar group, and the alternative is a dissolution group； And a heterocycle group or dissolution group； R3 is a hydrogen, halogen, cyanogen, C1-10 tar group or alcoxi C1-10 group； and a CF3, NRR and rsqoe group；,-NR-CO-R,-CONRR,-So2nrr rsqoe； R and R rsqoe； independently choose a C1-10 tar group between hydrogen, choose to be replaced by at least one C1-10 tar group, choose to be replaced by one C1-10 tar group, and a heteromorphic group or dissolution group； It is o or s； W is n or Cr4； R4 is hydrogen, cyanogen, CF3, halogen, a sulfopropyl compound C1-10, a group of C1-10 tar is replaced by at least one optional non atomic, a C1-10 tar group, optionally by a dissolution group； there is also an alcox C1-10 or a halogen-10 group.A dissolved group, a heteromorphic group, aSO2-NRR,-N
