МЭЙТС Шэрон (US),ДЭВИС Роберт (US),ЛИ Пэн (US),УЭННОДЖЛ Лоренс (US),ЛЕРНЕР Ричард А. (US)
申请号：
RU2014145682
公开号：
RU2014145682A
申请日:
2013.04.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound of formula I: where: X is N (H), N (C1-6alkyl) or O； R1 represents H or C1-6alkyl (for example methyl)； R2 represents H or OR, where R2 represents H or C1-6alkyl (for example methyl )； provided that R and Roba do not represent H, and R and Roba do not represent H； in free form or in salt form. 2. The compound of claim 1, wherein R is OR. 3. The compound of claim 2, wherein R1 is C1-6alkyl. 4. A compound according to claim 3, wherein R5 is methyl. A compound according to claim 1, wherein R is OR and R is C1-6alkyl. A compound according to claim 5, wherein R is OR and R is methyl. A compound according to claim 1, wherein X is N (C1-6alkyl) .8. The compound of claim 1, wherein X is O.9. The compound of claim 1, wherein X is N (H). 10. The compound of claim 7, wherein X is N (CH)； 11. A compound according to claim 1, which is: in free form or in salt form. A compound according to claim 1, which is: in free form or in salt form. A compound according to claim 1, wherein said compound is in salt form. A compound according to claim 13, wherein the salt is selected from the group consisting of toluenesulfonic, fumaric and phosphoric acid addition salts. A pharmaceutical composition comprising a compound according to claim 1, in combination or association with a pharmaceutically acceptable diluent or carrier. A method for treating or preventing a central nervous system disorder, comprising administering to a patient in need thereof a compound according to Claim 1.17. The method of claim 16, wherein said disorder is selected from the group consisting of obesity, anxiety, depression (e.g., refractory depression and MDD), psychosis, schizophrenia, sleep disorders (in particular, sleep disorders associated with schizophrenia and other psychiatric and neurological the disease1. Соединение формулы I:где:X представляет собой N(H), N(Салкил) или О；Rпредставляет собой Н или Салкил (например, метил)；Rпредставляет собой Н или OR, где Rпредставляет собой Н или Салкил (нап
