Provided herein are pharmaceutical and cosmetic formulations and methods for regional adiposity reduction and treatment of body contour defects such as abdominal bulging comprising an injectable formulation said formulation comprising: an active ingredient that consists essentially of an adipose tissue reducing amount of one or more lipophilic long acting selective beta 2 adrenergic receptor agonists or salts solvates or polymorphs thereof and one or more subcutaneously acceptable inactive ingredients.