федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения Российской Федерац
发明人:
Стогов Максим Валерьевич (RU),Борзунов Дмитрий Юрьевич (RU),Овчинников Евгений Николаевич (RU),Чегуров Олег Константинович (RU),Смоленцев Дмитрий Владимирович (RU),Гурин Максим Вячеславович (RU)
申请号：
RU2019113728
公开号：
RU0000191700U1
申请日:
2019.05.07
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The utility model relates to medical devices and can be used in the production of implants or grafts for traumatology, orthopedics, maxillofacial surgery, designed to replace bone tissue. The implant is made in the form of a bone block obtained from purified xenosity, preserving natural macro- and micropores, containing morphogenetic proteins, contains an antimicrobial agent. In this case, the antimicrobial preparation is located in the macro- and micropores of the bone block as part of a mixture with a biodegradable polymer (amorphous L, D-polylactide), or the macro- and micropores of the bone block are filled with an aqueous solution of the antimicrobial preparation vancomycin, at a concentration of 5 mg / ml. The bone block is aged in a hypertonic saline solution of sodium chloride NaCl with a concentration of 1% to 10% for 12 to 240 hours, aged in an ultrasonic bath with a solution of hydrogen peroxide, from 1% to 10%, for 12 to 240 hours, subjected to supercritical fluid extraction at a temperature of from 20 ° C to 70 ° C and a pressure of from 1000 psi to 10,000 psi for 30 to 500 minutes, subjected to lyophilization. The technical result is to provide pronounced antimicrobial activity, with a dosed prolonged release of antimicrobial the drug in the implantation zone. Despite the fact that the implant is a biological supporting framework for bone growth, has osteoinductive properties, is able to transform undifferentiated mesenchymal cells into osteoblasts, does not cause immunological rejection, the basis for its manufacture (xenosis) is widely available. 1 n and 5 z.p. f-ly, 1 ill.Полезная модель относится к медицинским изделиям и может быть использована в производстве имплантатов или трансплантатов для травматологии, ортопедии, челюстно-лицевой хирургии, предназначенных для замещения костной ткани.Имплантат выполнен в форме костного блока, полученного из очищенной ксенокости, сохранившей естественные макро- и микропоры, содержащий морфогенетические белки,
