Cristina Bongiorni,Rodante Gonzales Caguiat,Carol Marie Fioresi,Brian F. Schmidt,Anita Van Kimmenade,Chao Zhu
申请号：
US15529948
公开号：
US10683528B2
申请日:
2015.12.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates in general to bacterial cells having genetic alterations that result in increased expression of a protein of interest and methods of making and using such cells. Aspects of the present invention include altered Gram positive microorganisms having one or more a genetic alterations that reduce the expression of a gene in the sin operon, thereby resulting in the enhanced expression of one or more proteins of interest.
