A SIMPLIFIED AND IMPROVED METHOD FOR PREPARING AN ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOME OR POLYPLEX FOR SYSTEMIC ADMINISTRATION OF A THERAPEUTIC OR DIAGNOSTIC AGENT
A method of preparing an antibody- or antibody fragment-targeted cationicimmunoliposome or polymer complex comprises the steps of (a) preparing anantibody or antibody fragment (b) mixing said antibody or antibody fragmentwith a cationic liposome to form a cationic immunoliposome or with a cationicpolymer to form a polyplex and (c) mixing said cationic immunoliposome orsaid polyplex with a therapeutic or diagnostic agent to form said antibody- orantibody fragment-targeted cationic immunoliposome or polymer complex.