Graeme Freestone;Alan P. Kaplan;Joel Renick;Varsha Gupta
发明人:
Varsha Gupta,Joel Renick,Graeme Freestone,Alan P. Kaplan
申请号：
US13270982
公开号：
US09012470B2
申请日:
2011.10.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I in the manufacture of a medicament for the treatment of GABAA receptor associated disorders. The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
