Insulin drug-oligomer conjugate mixtures comprising polyalkylene glycols, their use, and methods for their production

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专利权人:

バイオコン・リミテッド

发明人:

ヌノキリ・エヌ・エクウリベ,クリストファー・エイチ・プライス,アスラム・エム・アンサリ,バラシンガム・ラダクリシュナン,エイミイ・エル・オーデンボウ

申请号：

JP2001316998

公开号：

JP5312720B2

申请日:

2001.10.15

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.

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中国工程科技知识中心

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http://www.ckcest.cn/home/