A compound represented by the general formula (I) or a salt thereof:[T represents oxygen atom and the like V represents CH2 and the like RO1 to RO4 represent hydrogen atom and the like A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like D represents carboxyl group and the like X represents ethylene group, trimethylene group and the like E represents -CH(OH)- group and the like and W represent -U1-(RW1)(RW2)-U2-U3 group (U1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like RW1 and RW2 represent hydrogen atom and the like U2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like and U3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.
