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STABILIZED SINGLE-LIQUID PHARMACEUTICAL COMPOSITION CONTAINING DOCETAXEL
专利权人:
LTD.;DONG-A PHARM.CO.
发明人:
CHA, BONG-JIN,KIM, JEONG-HOON,YOO, MOO-HI,JANG, SUN-WOO,WON, DONG-HAN
申请号:
NZ58757809
公开号:
NZ587578A
申请日:
2009.02.26
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a single-liquid pharmaceutical composition for injection containing docetaxel (formula 1) controlled in a pH range of 3.0 to 5.0, consisting of (A) docetaxel or pharmaceutically acceptable salts thereof; (B) a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol ester and polyoxyethylene castor oil derivatives; (C) an anhydrous ethanol in a concentration range of 100 to 800 mglml; and (D) a pH adjustor selected from the group consisting of citric acid, fumaric acid, lactic acid, stannic acid, succinic acid, maleic acid, acetic acid, tartaric acid, and phosphoric acid.
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