LEE, CHIA HWA,李嘉华,李嘉華,CHANG, YU JIA,张育嘉,張育嘉,HUANG, CHING SHUI,黄清水,黃清水,CHEN, CHING SHYANG,陈清祥,陳清祥,TU, SHIH HSIN,杜世兴,杜世興,WANG, YING JAN,王应然,王應然,TAM, KA WAI,谭家伟,譚家偉,WEI, PO LI,魏柏立,魏柏立,CHENG, TZU CHUN,郑自君
申请号：
TW100104874
公开号：
TWI501770B
申请日:
2011.02.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.本發明發現α9-nAChR之過度表現及活化與乳癌之癌化過程相關,並創造了一些小干擾RNA以抑制α9-nAChR之表現從而抑制乳癌。因此,本發明提供了可抑制α9-nAChR表現從而抑制乳癌之小干擾RNA及預防/抑制/治療尼古丁衍生化合物誘發之乳癌之惡性病程,以及確定此類乳癌惡性程度之方法。(無元件符號說明)
