具有雜雙芳基部分之類鐸受體7(TLR7)促效劑，其結合物及其等之方法及用途农业专利-农业学术服务平台

发明人:: HE, LIQI,何　立崎,GANGWAR, SANJEEV,刚沃　桑吉夫,剛沃　桑吉夫,POSY, SHOSHANA L.,波西　修夏娜　Ｌ,POUDEL, YAM B.,包杜尔　阳　Ｂ,包杜爾　陽　Ｂ,SIVAPRAKASAM, PRASANNA,希法普拉卡桑　普拉桑玛,希法普拉卡桑　普拉桑瑪

摘要：: Compounds having a structure according to formula (I) or (II)where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.本發明係關於具有式(I)或式(II)結構之化合物其中R1、R2及Ar如本文中所定義，該等化合物為類鐸受體7 (TLR7)之促效劑，且可用作用於刺激免疫系統之佐劑。一些此類化合物可以結合物形式使用以靶向遞送至預期作用之器官或組織。