N3 alkylated benzimidazole derivatives as MEK inhibitors农业专利-农业学术服务平台

发明人:: ウォレス、エリ、エム．,リシカトス、ジョゼフ、ピー．,マーロー、アリソン、エル．,ハーリー、ブライアン、ティー．,コッチ、ケビン,ウォレス、エリ、エム.,リシカトス、ジョゼフ、ピー.,マーロー、アリソン、エル.,ハーリー、ブライアン、ティー.

摘要：: Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R<；SUP>；1<；/SUP>；, R<；SUP>；2<；/SUP>；, R<；SUP>；7<；/SUP>；, R<；SUP>；8<；/SUP>；, R<；SUP>；9 <；/SUP>；and R<；SUP>；10 <；/SUP>；are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.