Jonathan B. Rothbard,Paul A. Wender,P. Leo McGrane,Lalitha V. S. Sista,Thorsten A. Kirschberg
申请号：
US11800358
公开号：
US08278264B2
申请日:
2007.05.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (for example, SEQ ID NO:86).
