GITR antibody specific bond provided herein. Provided GITR specific antibodies or antigen-binding fragment can be encoded by also having addressed related polynucleotides, express the antibody or its antigen-binding fragment and relevant vector, and the antibody of detectable label or its antigen-binding fragment in cell. In addition,Method uses the antibody. For example, provided antibody can be used for immune response anticancer in raising subject.