(R) -4- (Heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them

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专利权人:

ドムペ・ソチエタ・ペル・アツィオーニ

发明人:

モリコニ，アレッシオ,アラミニ，アンドレア,モリコニ,アレッシオ,アラミニ,アンドレア

申请号：

JP2010529394

公开号：

JP5374511B2

申请日:

2008.10.17

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention relates to a novel class of (R)-4-(heteroaryl)phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic activation induced by the fraction C5a of complement. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of autoimmune hemolytic anemia (AIHA), psoriasis, bullous pemphigoid, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion.

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