AN IMPROVED EXPRESSION CASSETTE FOR PACKAGING AND EXPRESSION OF VARIANT FACTOR VIII FOR THE TREATMENT OF HEMOSTASIS DISORDERS

• 收藏
• 分享

专利权人:

THE CHILDREN'S HOSPITAL OF PHILADELPHIA

发明人:

Denise SABATINO,Katherine A. HIGH,Liron ELKOUBY

申请号：

US15503120

公开号：

US20170233456A1

申请日:

2015.08.13

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/