The bright poxvirus being related to comprising I4L and/or F4L Ji because of Que Damage of this Hair is related to closing object comprising The poxvirus Group and Will The Group closes object and poxvirus controls the method and purposes of Treatment cancer with what with controlling Treatment purpose, Geng Ju Body with what.本發明涉及包含I4L和/或F4L基因缺損的痘病毒,涉及包含該痘病毒的組合物,以及將該組合物和痘病毒用於治療目的、更具體地用於治療癌症的方法和用途。