Thomas J. Wandless,Laura Anne Banaszynski,Mari Iwamoto,Lystranne Alysia Maynard,Ling-chun Chen
申请号：
US12069235
公开号：
US08173792B2
申请日:
2008.02.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.
