The prt invention is characterized in that a support, a drug layer, and a control layer are sequentially laminated, and the drug layer contains at least one drug selected from the group consisting of naflafin and salts thereof, and the stratum corneum and the like Is applied to the skin which is damaged and the skin barrier is insufficient, it is possible to maintain a constant amount of permeation of drug through the skin without causing an excessive amount of the drug to permeate through the skin within a short period of time, nalfurfine-containing transdermal absorption And a patch.本発明は、支持体、薬物層、および制御層が順次積層されてなり、薬物層がナルフラフィンおよびその塩からなる群より選択される少なくとも1種の薬物を含有することを特徴とし、角層などが損傷し皮膚バリアが不十分な皮膚に適用しても、短時間のうちに過剰量の薬物が皮膚を透過することがなく、かつ一定の薬物皮膚透過量を維持できる、ナルフラフィン含有経皮吸収貼付剤に関する。
