Her Majesty the Queen in the Right of Canada as Represented by the Minister of Health
发明人:
Xuguang Li,Gary Van Domselaar,Adrian Zetner
申请号：
US16648439
公开号：
US20200306363A1
申请日:
2018.11.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A synthetic hemagglutinin (sHA) which represents the highest degree of conservation in the HA sequences of all Influenza B viruses (IVB) based on comprehensive bioinformatics analyses was cloned into an adenoviral vector. The recombinant adenovirus carrying the sHA gene was then delivered intransallyintranasally into DAB/2 mice. The animals were challenged with 5xLD50 influenza B viruses. We have found that the synthetic HA vaccines afford 100% protection against lethal challenge whereas 50% mice died in the control group. Furthermore, no virus was found in the lung of the vaccinated group while significant lung viruses were found in all mice of the controlled group. Consistent with the survival data and virus titre, severe pneumonia was found in all mice of the control group while no pathologic observation was made in animals receiving the vaccines.
