HSIEH, PATRICK C. H.,谢清河,謝清河,CHANG, MIN YAO,张明曜,張明曜
申请号：
TW100117711
公开号：
TWI496581B
申请日:
2011.05.20
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention relates to a new type of functionalized nanoparticles for drug delivery, comprising a type of polymer nanoparticles, a polymer stabilizer coating, and a drug, wherein said polymer stabilizer coating is coated on the surface of said type of polymer nanoparticles, and said drug is electrostatically bound to or conjugated to said polymer stabilizer coating. The present invention also relates to a method for preparing the nanoparticles； and provides a method for treating an ischemic or degenerative disease, comprising administrating an effective amount of the type of functionalized nanoparticles to a subject.本發明係關於一種用於藥物遞送的新型功能性奈米粒子，包含一種聚合物奈米粒子，一聚合物穩定劑包覆層，以及一藥物；其中該聚合物穩定劑包覆層係包覆在該種聚合物奈米粒子的表面，且該藥物係與該聚合物穩定劑包覆層係為靜電吸附力結合或共軛結合。本發明亦關於一種製備該種奈米粒子之方法；並提供一種治療缺血性或退化性疾病的方法，包含對患者投予有效量的該種功能性奈米粒子。
