Provided is a medicine packaging machine in which even if a medicine guide structure (114) is constituted by first and second divided guide structures (114A, 114B), powder dust is hardly generated due to scraping of the first and second divided guide structures (114A, 114B). A gap between a pair of guide passages of a pair of linearly acting guide mechanisms (150, 150) provided for a pair of medicine feeder storage units (112, 112), the guide passage being a passage for a movable slide unit (152) to slide on the stationary guide unit (151), becomes wider in the drawing direction of the medicine feeder storage unit (112).
