A radial artery compression device configured to be releasably secured by a strap or band to the underside of a wrist of a patient and to provide adjustable and consistent compression pressure in the area of a radial artery access site to achieve hemostasis either during or after a medical procedure such as a percutaneous coronary procedure. The radial artery compression device includes a body configured to engage and secure a knob while allowing the knob to rotate with respect to the body. Rotation of the knob can cause a threaded shaft to move. The threaded shaft mechanically couples the knob to a disk-shaped compression pad. The compression pad can include one or more notches adapted to at least partially surround a sheath and/or a catheter inserted into the radial artery at the access site. The compression pad can also include a step on the surface to provide a desired amount of contour to a portion of a device within the radial artery during a procedure.
